G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral
membrane proteins to which histamine receptors belong. Increasing numbers of proteins …

In this article, we review the recent developments in the field of histamine research. Besides
the description of pharmacological tools for the H1, H2 and H3 receptor, specific attention is …

Histamine is a ubiquitous mediator in the body with numerous physiological and
pathological actions. In humans, there are four subtypes of histamine receptor, H1, H2, H3 …

G-protein-coupled receptors (GPCRs) represent the largest family of receptors involved in
transmembrane signaling. Although these receptors were generally believed to be …

In previous studies we showed that the wild-type histamine H2 receptor stably expressed in
Chinese hamster ovary cells is constitutively active. Because constitutive activity of the H2 …

The human histamine receptors hH 1 R and hH 2 R constitute important drug targets, and
hH 3 R and hH 4 R have substantial potential in this area. Considering the species …

Histamine mediates a multitude of physiological effects in the human body by activating four
histamine receptor subtypes. Histamine receptors have proven to be promising drug targets …

Histamine exerts its numerous physiological functions through interaction with G protein-
coupled receptors. Three such receptors have been defined at both the pharmacological …

In addition to its pivotal role in hypersensitivity reactions [10], smooth muscle contraction
[11], and vascular permeability [10, 12], we now know that histamine is produced and …

Previously reported pharmacological studies using the imidazole-containing histamine H3
receptor ligands GT-2331 (Cipralisant) and proxyfan resulted in a range of classifications …