Recirculation following 2 h of focal ischemia due to transient middle cerebral artery (MCA)
occlusion has previously been found to be accompanied by an initial, partial recovery of the …

The free radical trapping agents NXY-059 and α-phenyl-N-tert.-butylnitrone (PBN) markedly
reduce infarct volume, even when given 1 or 3 h after the start of recirculation, following 2 h …

Ischemia is accompanied by mitochondrial dysfunction, as assessed by measurements of
mitochondrial respiratory activities in vitro. Following brief periods of ischemia, mitochondrial …

It has been reported that immunosuppressant FK506 inhibited ischemic neuronal injury in
forebrain ischemia or transient focal cerebral ischemia, but the mechanisms of the …

The present experiments were undertaken to explore the mechanisms of secondary brain
damage in focal ischemia of long duration (2 h), followed by recirculation. Recirculation has …

The efflux of mitochondrial protein cytochrome C to cytoplasm is one of the key events of
mitochondrial dysfunction observed in post-ischemic pathology. We investigated the effect of …

FK506 is an immunosuppressive agent that has been reported to have neuroprotective
effects in several kinds of rodent models of stroke. The purpose of this study was to evaluate …

In the present experiments, we compared the anti-ischemic effects of the
immunosuppressants cyclosporin A (CsA) and FK506 in hyperglycemic animals subjected to …

The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in
a rat model of transient cerebral ischemia induced by occlusion of both common carotid …

Cerebral ischemia followed by reperfusion activates numerous pathways that lead to cell
death. One such pathway involves the release of large quantities of the excitatory amino …