The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Leptin is an adipocyte-derived hormone that primarily acts in the hypothalamus and plays a
key role in the regulation of food intake, body weight, energy expenditure and …

The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism;
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …

The fat‐derived hormone, leptin, is well known to regulate body weight. However, there is
now substantial evidence that leptin also plays a primary role in the regulation of glucose …

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Since the discovery of leptin in 1994, we now have a better understanding of the cellular and
molecular mechanisms underlying its biological effects. In addition to its established anti …

Leptin is hypothesized to function as a negative feedback signal in the regulation of energy
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …

Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …