Prospects for new drugs for chronic obstructive pulmonary disease

PJ Barnes, TT Hansel - The Lancet, 2004 - thelancet.com
No currently available treatments have been shown to slow the progression of chronic
obstructive pulmonary disease (COPD) or suppress the inflammation in small airways and …

The future of chronic obstructive pulmonary disease treatment—difficulties of and barriers to drug development

FJ Martinez, JF Donohue, SI Rennard - The Lancet, 2011 - thelancet.com
Although chronic obstructive pulmonary disease (COPD) is a major global health problem
with a rising incidence and morbidity, few pharmacotherapeutic advances have been made …

New drugs for exacerbations of chronic obstructive pulmonary disease

TT Hansel, PJ Barnes - The Lancet, 2009 - thelancet.com
Tobacco smoking is the dominant risk factor for chronic obstructive pulmonary disease
(COPD), but viral and bacterial infections are the major causes of exacerbations in later …

Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission

D Stolz, T Mkorombindo, DM Schumann, A Agusti… - The Lancet, 2022 - thelancet.com
Executive summary Despite substantial progress in reducing the global impact of many non-
communicable diseases, including heart disease and cancer, morbidity and mortality due to …

New treatments for chronic obstructive pulmonary disease

PJ Barnes - Current opinion in pharmacology, 2001 - Elsevier
No currently available drugs prevent the progression of chronic obstructive pulmonary
disease, one of the leading causes of morbidity and mortality worldwide. Several new drugs …

COPD: current therapeutic interventions and future approaches

PJ Barnes, RA Stockley - European Respiratory Journal, 2005 - Eur Respiratory Soc
Although long-acting bronchodilators have been an important advance for the management
of chronic obstructive pulmonary disease (COPD), these drugs do not deal with the …

Chronic obstructive pulmonary disease and comorbidities

M Decramer, W Janssens - The Lancet Respiratory Medicine, 2013 - thelancet.com
Results of epidemiological studies have shown that chronic obstructive pulmonary disease
(COPD) is frequently associated with comorbidities, the most serious and prevalent being …

New therapies for chronic obstructive pulmonary disease

PJ Barnes - Medical Principles and Practice, 2010 - karger.com
Chronic obstructive pulmonary disease (COPD) is a major global health problem which is
increasing throughout the world and a major cause of death. However, current therapies fail …

Treatment of stable chronic obstructive pulmonary disease

SI Rennard - The Lancet, 2004 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a readily diagnosable disorder that
responds to treatment. Smoking cessation can reduce symptoms and prevent progression of …

Future advances in COPD therapy

PJ Barnes - Respiration, 2001 - karger.com
There is a pressing need for more effective drug treatments for COPD. New bronchodilators
include a long-acting anticholinergic tiotropium bromide and a dual β 2-dopamine 2 …