Genomic and Transcriptomic Approaches Provide a Predictive Framework for Sesquiterpenes Biosynthesis in Desarmillaria tabescens CPCC 401429

T Zhang, J Feng, W He, X Rong, H Lv, J Li, X Li… - Journal of Fungi, 2023 - mdpi.com
Terpenoids constitute a structurally diverse class of secondary metabolites with wide
applications in the pharmaceutical, fragrance and flavor industries. Desarmillaria tabescens …

Genome of Diaporthe sp. provides insights into the potential inter-phylum transfer of a fungal sesquiterpenoid biosynthetic pathway

JG de Sena Filho, MB Quin, DJ Spakowicz, JJ Shaw… - Fungal biology, 2016 - Elsevier
Fungi have highly active secondary metabolic pathways which enable them to produce a
wealth of sesquiterpenoids that are bioactive. One example is Δ6-protoilludene, the …

Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases

Z Cong, Q Yin, K Tian, NJ Mukoma, L Ouyang… - Journal of Fungi, 2024 - mdpi.com
Sesquiterpenoids served as an important source for natural product drug discovery.
Although genome mining approaches have revealed numerous novel sesquiterpenoids and …

Predicting functions of putative fungal sesquiterpene synthase genes based on multiomics data analysis

T Nosenko, I Zimmer, A Ghirardo, TG Köllner… - Fungal Genetics and …, 2023 - Elsevier
Sesquiterpenes (STs) are secondary metabolites, which mediate biotic interactions between
different organisms. Predicting the species-specific ST repertoires can contribute to …

Agrocybe aegerita Serves As a Gateway for Identifying Sesquiterpene Biosynthetic Enzymes in Higher Fungi

C Zhang, X Chen, A Orban, S Shukal, F Birk… - ACS Chemical …, 2020 - ACS Publications
Terpenoids constitute a structurally diverse group of natural products with wide applications
in the pharmaceutical, nutritional, flavor and fragrance industries. Fungi are known to …

Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota

GT Wawrzyn, MB Quin, S Choudhary… - Chemistry & biology, 2012 - cell.com
The secondary metabolome of Basidiomycota represents a largely uncharacterized source
of pharmaceutically relevant natural products. Terpenoids are the primary class of bioactive …

Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining

XL Li, YX Xu, Y Li, R Zhang, TY Hu, P Su… - Fungal Genetics and …, 2019 - Elsevier
Basidiomycete fungi are a rich source of bioactive diterpenoid secondary metabolites.
However, compared with the large number of diterpene synthases (di-TPSs) identified in …

Mushroom hunting by using bioinformatics: application of a predictive framework facilitates the selective identification of sesquiterpene synthases in basidiomycota

MB Quin, CM Flynn, GT Wawrzyn, S Choudhary… - …, 2013 - Wiley Online Library
The Basidiomycota fungi represent a diverse source of natural products, particularly the
sesquiterpenoids. Recently, genome sequencing, genome mining, and the subsequent …

[HTML][HTML] Recent Advances and New Insights in Genome Analysis and Transcriptomic Approaches to Reveal Enzymes Associated with the Biosynthesis of Dendrobine …

X Qian, S Sarsaiya, Y Dong, T Yu, J Chen - Molecules, 2024 - mdpi.com
Dendrobium species, which are perennial herbs widely distributed in tropical and
subtropical regions, are notable for their therapeutic properties attributed to various bioactive …

Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus

J Chen, X Zeng, YL Yang, YM Xing, Q Zhang, JM Li… - Scientific reports, 2017 - nature.com
The lion's mane mushroom Hericium erinaceus is a famous traditional medicinal fungus
credited with anti-dementia activity and a producer of cyathane diterpenoid natural products …