A series of 38 thiosemicarbazone derivatives based on camphene and limonene were
evaluated for their antiproliferative activity. Among them, 19 were synthesized and …

In an attempt to develop potent and selective antitumor agents, a series of novel
thiosemicarbazones derived from a natural monoterpene R-(+)-limonene was synthesized …

Thiosemicarbazones (TSCs) are interesting group of chemical compounds that received
significant levels of attention due their wide range of pharmacological effects including …

Aims This study evaluated parameters of toxicity and antiproliferative effects of (+)-N (1)-4-
fluorobenzaldehyde-N (4)-{1-methyl-1-[(1 R)-4-methylcyclohexene-3-il]-ethyl} …

Melanoma, the deadliest form of skin cancer, is still one of the most difficult cancers to treat
despite recent advances in targeted and immune therapies. About 50% of advanced …

Melanomas are heterogeneous and aggressive tumors, and one of the worse in prognosis.
Melanoma subtypes follow distinct pathways until terminal oncogenic transformation. Here …

The present study aimed to investigate the cytotoxic effect of 38 new thiosemicarbazone
derivatives on hematological neoplastic cells lines and to select the most effective …

Background: Considering the need for the development of new antitumor drugs, associated
with the great antitumor potential of thiophene and thiosemicarbazonic derivatives, in this …

Acute leukemias are a heterogeneous group of aggressive malignant neoplasms associated
with severe morbidities due to the nonselectivity of current chemotherapeutic drugs to …

To discover novel anticancer agents with potent and low toxicity, we designed and
synthesized a range of new thiosemicarbazone-indole analogues based on lead compound …