Abstract The ABCB1/MDR-1 gene, which encodes P-glycoprotein, is highly polymorphic. We
analyzed 278 healthy Brazilian individuals through PCR–RFLP to identify ABCB1 variants …

The aim of this study was to evaluate the most common ABCB1 (MDR1, P-glycoprotein)
polymorphisms in the population of R. Macedonia and compare the allele and haplotype …

Abstract Objective The ABCB1 (MDR1) multidrug transporter plays a key role in determining
drug bioavailability. Differences in drug response exist among different ethnic groups …

Introduction: The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes
for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer …

Objective The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to
act on a broad range of prescription medicines. For this reason a large number of studies …

In 1976, Juliano and Ling 1 reported expression of a 170 kDa protein in colchicine‐resistant
Chinese hamster ovary (CHO) cells that was absent in drug‐sensitive cells. Because this …

As functional ABCB1 haplotypes were recently reported in the promoter region of the gene,
we resequenced the ABCB1 distal promoter region, along with other regions (the enhancer …

The most widely studied polymorphisms of the ABCB1 gene are rs1128503 (c. 1236C> T),
rs2032582 (c. 2677G> T/A), and rs1045642 (c. 3435C> T). Although variation in ABCB1 …

Introduction: Interethnic admixture is a source of cryptic population structure that may lead to
spurious genotype–phenotype associations in pharmacogenomic studies. We studied the …

A noncoding C3435T mutation in exon 26 of the ABCB1 gene was found to be often
associated with a G2677T (A) mutation in exon 21 encoding an Ala893Ser P-glycoprotein …