The challenge and prospect of mRNA therapeutics landscape
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …
in the pharmaceutical industry because they can be used for precise and individualized …
mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
mRNA vaccine era—mechanisms, drug platform and clinical prospection
S Xu, K Yang, R Li, L Zhang - International journal of molecular sciences, 2020 - mdpi.com
Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …
mRNA nanomedicine: Design and recent applications
LJ Kubiatowicz, A Mohapatra, N Krishnan… - …, 2022 - Wiley Online Library
The rational design and application of mRNA‐based medicine have recently yielded some
key successes in the clinical management of human diseases. mRNA technology allows for …
key successes in the clinical management of human diseases. mRNA technology allows for …
[HTML][HTML] The pivotal role of chemical modifications in mRNA therapeutics
A Liu, X Wang - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
After over a decade of development, mRNA has recently matured into a potent modality for
therapeutics. The advantages of mRNA therapeutics, including their rapid development and …
therapeutics. The advantages of mRNA therapeutics, including their rapid development and …
An overview of rational design of mRNA-based therapeutics and vaccines
KKW To, WCS Cho - Expert opinion on drug discovery, 2021 - Taylor & Francis
ABSTRACT Introduction Messenger RNA (mRNA)-based therapeutics and vaccines have
emerged as a disruptive new drug class for various applications, including regenerative …
emerged as a disruptive new drug class for various applications, including regenerative …
Tools for translation: non-viral materials for therapeutic mRNA delivery
KA Hajj, KA Whitehead - Nature Reviews Materials, 2017 - nature.com
In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
mRNA therapeutics deliver a hopeful message
Z Zhong, S Mc Cafferty, F Combes, H Huysmans… - Nano today, 2018 - Elsevier
Messenger RNA based therapeutics have the potential to cause a big revolution in medicine
as they can facilitate personalized medicines and allow patients to produce their own …
as they can facilitate personalized medicines and allow patients to produce their own …
Therapeutic mRNA engineering from head to tail
Conspectus Synthetic messenger RNA (mRNA), once delivered into cells, can be readily
translated into proteins by ribosomes, which do not distinguish exogenous mRNAs from …
translated into proteins by ribosomes, which do not distinguish exogenous mRNAs from …
[HTML][HTML] Delivering the messenger: advances in technologies for therapeutic mRNA delivery
mRNA has broad potential as a therapeutic. Current clinical efforts are focused on
vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical …
vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical …