Methods: PubMed, Scopus and Embase databases were systematically queried to obtain
records pertaining to the etiology of and treatment for MBM. Clinical trial databases were …

Introduction Introduction: Melanoma continues to represent the most serious skin cancer
worldwide. However, few attempts have been made to connect the body of research on …

Background The development of brain metastases is common in patients with melanoma
and is associated with a poor prognosis. Treating patients with melanoma brain metastases …

Abstract Development of brain metastasis is one of the most serious complications of
advanced melanoma, carrying a significant burden of morbidity and mortality. Although …

The remarkable advances in the systemic therapy of metastatic melanoma have now
extended the 1-year overall survival rate from 25% to nearing 85%. Systemic treatment in …

Patients with melanoma brain metastases (MBM) have a dismal prognosis, but the
unprecedented advances in systemic therapy alone or in combination with local therapy …

Brain metastases are the most common brain malignancy. This review discusses the studies
presented at the third annual meeting of the Melanoma Research Foundation in the context …

Of the solid tumor types that metastasize to the brain, melanoma has the highest propensity
to form brain metastases. In addition, much remains unknown regarding the …

Patients with melanoma brain metastases (MBM) still have a very poor prognosis. Several
treatment modalities have been investigated in an attempt to improve the management of …

Melanoma brain metastases (MBM) are common and associated with a particularly poor
prognosis; they directly cause death in 60–70% of melanoma patients. In the past, systemic …