Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new
bone formation and affects millions of women worldwide. Melatonin can improve bone …

Background Osteoporosis is a disease threatening the health of millions of individuals.
Melatonin is found to be a potential anti-osteoporosis drug. However, whether melatonin …

Melatonin, a pineal gland hormone, has been suggested to treat postmenopausal
osteoporosis due to its inhibitory effect on osteoclast differentiation. We previously reported …

Background The protective effect of melatonin against bone metabolism imbalance in
osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this …

Melatonin is an important endogenous hormone that modulates homeostasis in the
microenvironment. Recent studies have indicated that serum melatonin levels are closely …

Growing evidence shows that the inhibitory effect of inflammatory cytokines on new bone
formation by osteogenic precursor cells is a critical cause of net bone‐density reduction …

Background and Purpose Melatonin is a neurohormone involved in bone homeostasis.
Melatonin directs bone remodelling and the role of bone marrow mesenchymal stem cells …

Osteoporosis is a systemic bone metabolism disease that often causes complications, such
as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain …

Oxidative stress is an important contributor to the development of osteoporosis. Melatonin,
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to …

Osteoblastic differentiation and bone‐forming capacity are known to be suppressed under
hypoxic conditions. Melatonin has been shown to influence cell differentiation. A number of …