Background In CT scans of smokers with COPD, the subsegmental airway wall area percent
(WA%) is greater and more strongly correlated with FEV 1% predicted than WA% obtained …

Background Increased airway wall thickness (AWT) and parenchymal lung destruction
bothcontribute to airflow limitation. Advances in computed tomography (CT) post-processing …

Background Partial volume averaging and tilt relative to the scan plane on transverse
images limit the accuracy of airway wall thickness measurements on CT scan, confounding …

Background: Chronic obstructive pulmonary disease (COPD) is characterized by airflow
obstruction caused by emphysema or airway narrowing, or both. Recently airway …

Background An increase in airway caliber (airway distensibility) with lung inflation is
attenuated in COPD. Furthermore, some subjects have a decrease in airway caliber with …

Background CT scan measures of emphysema and airway disease have been correlated
with lung function in cohorts of subjects with a range of COPD severity. The contribution of …

PURPOSE: To design and validate a dedicated software tool to measure airway dimensions
on thin-section computed tomographic (CT) images and to use the tool to prospectively …

Bronchial wall area percent (WA%= 100× wall area/total bronchial cross sectional area) is a
standard computed tomographic (CT) measure of central airway morphology utilized in …

Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow
obstruction caused by emphysema or airway narrowing, or both. Low attenuation areas …

Background Recently, it has been shown that emphysematous destruction of the lung is
associated with a decrease in the total number of terminal bronchioles. It is unknown …