新規の有用な化学物質の研究開発において, その安全性確保は最大の課題の
うちの一つであることはいうまでもない. 農薬, 医薬品等ではその上市までに急性, 亜急性, 慢性 …

The carcinogenic potential of 5 pesticides was analyzed using a medium‐term multi‐organ
bioassay for carcinogenicity. Male F344 rats were initially treated with 3 known carcinogens …

The question may be asked why the National Cancer Institute, a research agency, should be
involved in studies on pesticides. In 1961, when the Etiology Area (formerly Field Studies) of …

JRP Cabral International Agency for Research on Cancer (IARC) Lyon, france What is a
pesticide? A pesticide is a substance ca Page 1 CARCINOGENICITY Of PESTICIDES JRP …

Short-term tests to detect genetic, chromosomal, or DNA damage are now required by
regulatory agencies for any new compound proposed for commercial production …

The tumorigenicity of selected pesticides and industrial compounds was tested by
continuous oral administration to both sexes of two hybrid strains of mice, started at the age …

In the last few years, marked progress has been made in the development of methods for
evaluating the mutagenic and carcinogenic potential of pesticide chemicals. The correlation …

AlIa nota serie di pubblicazioni edite dalla IARC in tema di cancerogenesi chimica, si
aggiunge il volume «Screening Tests in Chemical Carcinogenesis» che raccoglie i …

The sophistication, sensitivity, and the predicability of carcinogenesis bioassays using small
rodents is reviewed. Bioassays were conducted using both sexes of mice (B6C3F1 …

Laboratory testing of pharmaceutical agents for possible tumorigenic activity plays a crucial
role in the identification of cancer risks associated with the use of such agents …