Acute respiratory distress syndrome (ARDS) is a common and devastating syndrome that
contributes to serious morbidities and mortality in critically ill patients. No known …

Aim: Platelet function is intricately linked to the pathophysiology of critical Illness, and some
studies have shown that antiplatelet therapy (APT) may decrease mortality and incidence of …

Background Antiplatelet agents are commonly used for cardiovascular diseases, but their
pleiotropic effects in critically ill patients are controversial. We therefore performed a meta …

Acute lung injury (ALI) is a common syndrome associated with a high mortality rate. Better
understanding of the pathophysiology of acute lung injury and progress in supportive care …

Platelets have an emerging and incompletely understood role in a myriad of host immune
responses, extending their role well beyond regulating thrombosis. Acute respiratory …

Rationale: Acute respiratory distress syndrome (ARDS) is a devastating illness with limited
therapeutic options. A better understanding of early biochemical and immunological events …

Sepsis, acute lung injury, and ARDS contribute substantially to the expanding burden of
critical illness within our ICUs. Each of these processes is characterized by a myriad of …

Sepsis is a common condition that is associated with significant morbidity, mortality and
health-care cost. Pulmonary and non-pulmonary sepsis are common causes of the acute …

Background: The acute respiratory distress syndrome (ARDS) is a life-threating disorder that
contributes significantly to critical illness. No specific pharmacological interventions directed …

Background Acute lung injury (ALI) is a potentially fatal lung disease with few treatment
options. Platelet activation is a key component of ALI pathophysiology and may provide an …