Estrogen synthesis and signaling pathways during aging: from periphery to brain

J Cui, Y Shen, R Li - Trends in molecular medicine, 2013 - cell.com
Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

Tissue-specific effects of loss of estrogen during menopause and aging

K Wend, P Wend, SA Krum - Frontiers in endocrinology, 2012 - frontiersin.org
The roles of estrogens have been best studied in the breast, breast cancers, and in the
female reproductive tract. However, estrogens have important functions in almost every …

Estrogen activates rapid signaling in the brain: role of estrogen receptor α and estrogen receptor β in neurons and glia

AJ Mhyre, DM Dorsa - Neuroscience, 2006 - Elsevier
The aging process is known to coincide with a decline in circulating sex hormone levels in
both men and women. Due to an increase in the average lifespan, a growing number of post …

Brain sex matters: estrogen in cognition and Alzheimer's disease

R Li, J Cui, Y Shen - Molecular and cellular endocrinology, 2014 - Elsevier
Estrogens are the primary female sex hormones and play important roles in both
reproductive and non-reproductive systems. Estrogens can be synthesized in non …

Estrogen receptors and the aging brain

S Maioli, K Leander, P Nilsson… - Essays in Biochemistry, 2021 - portlandpress.com
The female sex hormone estrogen has been ascribed potent neuroprotective properties. It
signals by binding and activating estrogen receptors that, depending on receptor subtype …

Estrogen and cancer

J Liang, Y Shang - Annual review of physiology, 2013 - annualreviews.org
Estrogen exhibits a broad spectrum of physiological functions ranging from regulation of the
menstrual cycle and reproduction to modulation of bone density, brain function, and …

Molecular mechanisms, physiological consequences and pharmacological implications of estrogen receptor action

T Barkhem, S Nilsson, JÅ Gustafsson - American Journal of …, 2004 - Springer
The estrogen receptors (ERs), ERα and ERβ, play a central role in mediating the biological
effects of estrogen. The transcription rate of estrogen target genes is determined by several …

Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice

SO Mueller, KS Korach - Current opinion in pharmacology, 2001 - Elsevier
The estrogen receptors ERα and ERβ are the main mediators of estrogen action and
estrogens play an important role in a variety of aspects of physiology besides their well …

Estrogen receptors and human disease

BJ Deroo, KS Korach - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
Estrogens influence many physiological processes in mammals, including but not limited to
reproduction, cardiovascular health, bone integrity, cognition, and behavior. Given this …

Sex hormones and cardiometabolic health: role of estrogen and estrogen receptors

D Clegg, AL Hevener, KL Moreau, E Morselli… - …, 2017 - academic.oup.com
With increased life expectancy, women will spend over three decades of life
postmenopause. The menopausal transition increases susceptibility to metabolic diseases …