Background The patients with dual oesophageal squamous cell carcinoma (ESCC) and
hypopharyngeal cancer (HPC) have poor prognosis; their underlying genetic pathogenesis …

Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma
(ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA …

Introduction In the era of precision preventive medicine, susceptible genetic markers for oro‐
/hypopharyngeal squamous cell carcinoma (OPSCC) have been investigated for genome …

Background The prognoses of head and neck squamous cell carcinoma (HNSCC) and
esophageal squamous cell carcinoma (ESCC) are poor, especially when both tumors occur …

Background & Aims Esophageal squamous cell carcinoma (ESCC) is the predominant form
of esophageal cancer in Japan. Smoking and drinking alcohol are environmental risk factors …

BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is prevalent among
Asian populations, with marked regional variations in incidence and mortality. Patients with …

Synchronous multiple intra-esophageal squamous cell carcinomas (SCCs) or
oropharyngolaryngeal SCCs are common in alcoholics with esophageal SCC, and more …

Objectives/Hypothesis Human papillomavirus (HPV) is a risk factor for head and neck
squamous cell carcinoma (HNSCC) as well as esophageal squamous cell carcinoma …

The upper aerodigestive tract (UADT) is highly susceptible to multiple primary cancers
originated from squamous epithelia and constitutes a field of cancerization. Patients with …

Multiple primary tumors (MPT), especially in the hypopharynx and esophagus, are
challenging in patients with head and neck cancer (HNC). Alcohol and alcohol-metabolizing …