The lens has been considered to be an immune privileged site not susceptible to the
immune processes normally associated with tissue injury and wound repair. However, as …

Immune cells, both tissue resident immune cells and those immune cells recruited in
response to wounding or degenerative conditions, are essential to both the maintenance …

Emerging evidence challenges the lens as an immune-privileged organ. Here, we provide a
direct mechanism supporting a role of macrophages in lens capsule rupture repair. Posterior …

The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Recent reports have challenged the notion that the lens is immune-privileged. However,
these studies have not fully identified the molecular mechanism (s) that promote immune …

Tissues typically harbor subpopulations of resident immune cells that function as rapid
responders to injury and whose activation leads to induction of an adaptive immune …

Background This work elucidates the first cellular and molecular causes of cataractogenesis.
Current paradigm presupposes elevated blood glucose as a prerequisite in diabetic …

Epithelial–mesenchymal transition (EMT) produces myofibroblasts that contribute to the
formation of fibrotic tissue with an impairment of tissue homeostasis and functionality. The …

Injury to the ocular lens perturbs cell-cell and cell-capsule/basement membrane interactions
leading to a myriad of interconnected signaling events. These events include cell-adhesion …

Background Previous studies have suggested that macrophages are present during lens
regeneration in newts, but their role in the process is yet to be elucidated. Methods Here we …