Mechanism of inflammasomes in cancer and targeted therapies

Q Gu, J Zou, Y Zhou, Q Deng - Frontiers in Oncology, 2023 - frontiersin.org
Inflammasomes, composed of the nucleotide-binding oligomerization domain (NOD)-like
receptors (NLRs), are immune-functional protein multimers that are closely linked to the host …

The roles of inflammasomes in cancer

Z Deng, L Lu, B Li, X Shi, H Jin, W Hu - Frontiers in Immunology, 2023 - frontiersin.org
Inflammation is a key characteristic of all stages of tumor development, including tumor
initiation, progression, malignant transformation, invasion, and metastasis. Inflammasomes …

Insights into inflammasome and its research advances in cancer

X Cao, J Xu - Tumori Journal, 2019 - journals.sagepub.com
Inflammation has long been proven to engage in tumor initiation and progression.
Inflammasome, as a member of innate immunity-induced host defense inflammation, also …

Inflammasome as a promising therapeutic target for cancer

C Lee, HTT Do, J Her, Y Kim, D Seo, I Rhee - Life sciences, 2019 - Elsevier
Inflammasomes are the major mechanistic complexes that include members of the NOD-like
receptor (NLRs) or AIM2-like receptors (ALRs) families, which are affiliated with the innate …

Inflammasome inhibitors: promising therapeutic approaches against cancer

S Xu, X Li, Y Liu, Y Xia, R Chang, C Zhang - Journal of hematology & …, 2019 - Springer
Inflammation has long been accepted as a key component of carcinogenesis. During
inflammation, inflammasomes are potent contributors to the activation of inflammatory …

Inflammasomes in cancer: a double-edged sword

R Kolb, GH Liu, AM Janowski, FS Sutterwala… - Protein & …, 2014 - academic.oup.com
Chronic inflammatory responses have long been observed to be associated with various
types of cancer and play decisive roles at different stages of cancer development …

Inflammasomes in inflammation-induced cancer

C Lin, J Zhang - Frontiers in immunology, 2017 - frontiersin.org
The inflammasome is an important multiprotein complex that functions during inflammatory
immune responses. The activation of inflammasome will lead to the autoactivation of …

[HTML][HTML] The inflammasome: an emerging therapeutic oncotarget for cancer prevention

W Zhiyu, N Wang, Q Wang, C Peng, J Zhang, P Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Deregulated inflammation is considered to be one of the hallmarks of cancer initiation and
development regulation. Emerging evidence indicates that the inflammasome plays a …

Beneficial and detrimental roles of NLRs in carcinogenesis

AM Janowski, R Kolb, W Zhang… - Frontiers in …, 2013 - frontiersin.org
Inflammation plays a critical role in tumorigenesis and can contribute to oncogenic
mutations, tumor promotion, and angiogenesis. Tumor-promoting inflammation is driven by …

Role of the NLRP3 inflammasome in cancer

M Moossavi, N Parsamanesh, A Bahrami, SL Atkin… - Molecular cancer, 2018 - Springer
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in
the cytosolic compartment as an inflammatory immune response to endogenous danger …