[HTML][HTML] Accelerating the prediction and discovery of peptide hydrogels with human-in-the-loop

T Xu, J Wang, S Zhao, D Chen, H Zhang… - Nature …, 2023 - nature.com
The amino acid sequences of peptides determine their self-assembling properties. Accurate
prediction of peptidic hydrogel formation, however, remains a challenging task. This work …

Design of self-assembly dipeptide hydrogels and machine learning via their chemical features

F Li, J Han, T Cao, W Lam, B Fan… - Proceedings of the …, 2019 - National Acad Sciences
Hydrogels that are self-assembled by peptides have attracted great interest for biomedical
applications. However, the link between chemical structures of peptides and their …

Recent trends in peptide and protein-based hydrogels

P Katyal, F Mahmoudinobar, JK Montclare - Current Opinion in Structural …, 2020 - Elsevier
Highlights•Hydrogels have revolutionized the field of biomaterials, with peptide and protein-
based systems emerging as versatile platforms.•Stimuli-responsive hydrogels respond to …

[HTML][HTML] Will it gel? Successful computational prediction of peptide gelators using physicochemical properties and molecular fingerprints

JK Gupta, DJ Adams, NG Berry - Chemical science, 2016 - pubs.rsc.org
The self-assembly of low molecular weight gelators to form gels has enormous potential for
cell culturing, optoelectronics, sensing, and for the preparation of structured materials. There …

Exploring the sequence space for (tri-) peptide self-assembly to design and discover new hydrogels

PWJM Frederix, GG Scott, YM Abul-Haija… - Nature …, 2015 - nature.com
Peptides that self-assemble into nanostructures are of tremendous interest for biological,
medical, photonic and nanotechnological applications. The enormous sequence space that …

Molecular, local, and network-level basis for the enhanced stiffness of hydrogel networks formed from coassembled racemic peptides: predictions from Pauling and …

K Nagy-Smith, PJ Beltramo, E Moore, R Tycko… - ACS central …, 2017 - ACS Publications
Hydrogels prepared from self-assembling peptides are promising materials for medical
applications, and using both l-and d-peptide isomers in a gel's formulation provides an …

The delicate balance between gelation and crystallisation: structural and computational investigations

DJ Adams, K Morris, L Chen, LC Serpell, J Bacsa… - Soft Matter, 2010 - pubs.rsc.org
Predicting the ability of low molecular weight molecules to form hydrogels is difficult. Here,
we have examined the self-assembly behavior of two chemically and structurally similar …

Rational design and application of responsive α-helical peptide hydrogels

EF Banwell, ES Abelardo, DJ Adams, MA Birchall… - Nature materials, 2009 - nature.com
Biocompatible hydrogels have a wide variety of potential applications in biotechnology and
medicine, such as the controlled delivery and release of cells, cosmetics and drugs, and as …

A Short Peptide Hydrogel with High Stiffness Induced by 310‐Helices to β‐Sheet Transition in Water

SH Hiew, H Mohanram, L Ning, J Guo… - Advanced …, 2019 - Wiley Online Library
Biological gels generally require polymeric chains that produce long‐lived physical
entanglements. Low molecular weight colloids offer an alternative to macromolecular gels …

Peptide hydrogels

A Dasgupta, JH Mondal, D Das - Rsc Advances, 2013 - pubs.rsc.org
This review covers an important class of soft-materials–peptide-based hydrogels,
distinctively focussing on the different types of small peptide/low molecular weight and …