So far, investigations into the neural basis of affect have revealed discrete, anatomically
localized sites called hedonic “hotspots” in nucleus accumbens (NAc) and ventral pallidum …

Pleasure is mediated by well-developed mesocorticolimbic circuitry and serves adaptive
functions. In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affect) …

Mesocorticolimbic systems are heavily implicated in the control of reward. Reward contains
multiple components that include 'liking','wanting', and learning processes (Berridge, 2004; …

The study of the neural bases of eating behavior, hunger, and reward has consistently
implicated the lateral hypothalamus (LH) and its interactions with mesocorticolimbic circuitry …

Hedonic “liking” for sensory pleasures is an important aspect of reward, and excessive
'liking'of particular rewards might contribute to excessive consumption and to disorders such …

μ-Opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens
shell (NAc) or the ventral pallidum (VP) amplifies hedonic “liking” reactions to sweetness …

What brain reward systems mediate motivational 'wanting'and hedonic 'liking'for food
rewards? And what roles do those systems play in eating disorders? This article surveys …

Highlights•Food rewards elicit affective responses that emerge from multiple
components.•These components are known to rely on distinct neurobiological …

Introduction Pleasure and reward are generated by brain circuits that are largely shared
between humans and other animals. Discussion Here, we survey some fundamental topics …

Ann Kelley was a scientific pioneer in reward neuroscience. Her many notable discoveries
included demonstrations of accumbens/striatal circuitry roles in eating behavior and in food …