Plasmodium falciparum infections can cause severe malaria, but not every infected person
develops life-threatening complications. In particular, carriers of the structural …

Many intracellular pathogens remodel the actin of their host cells, and the human malaria
parasite Plasmodium falciparum is no exception to this rule. The surprising finding is that …

Sickle cell trait (AS) confers partial protection against lethal Plasmodium falciparum malaria.
Multiple mechanisms for this have been proposed, with a recent focus on aberrant …

The hemoglobins S and C protect carriers from severe Plasmodium falciparum malaria.
Here, we found that these hemoglobinopathies affected the trafficking system that directs …

Plasmodium falciparum shields from adaptive immunity in erythrocytes, but how might the
innate immune system recognize infected cells? Replication by the parasite results in …

Malaria is a potentially deadly disease. However, not every infected person develops severe
symptoms. Some people are protected by naturally occurring mechanisms that frequently …

Background α-thalassemia results from decreased production of α-globin chains that make
up part of hemoglobin tetramers (Hb; α2β2) and affects up to 50% of individuals in some …

Plasmodium falciparum malaria kills over 500,000 children every year and has been a
scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum …

Sickle cell trait, a common hereditary blood disorder, protects carriers from severe disease in
infections with the human malaria parasite Plasmodium falciparum. Protection is associated …

Malaria is a highly inflammatory disease caused by the protozoan parasite Plasmodium.
During the blood stage of infection, patients exhibit fever with high levels of inflammatory …