Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice
Introduction Choroidal neovascularization (CNV) in age-related macular degeneration
(AMD) leads to blindness. It has been widely reported that increased intake of ω− 3 long …
(AMD) leads to blindness. It has been widely reported that increased intake of ω− 3 long …
Cytochrome P450 oxidase 2C inhibition adds to ω-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal neovascularization
Objective—Pathological ocular neovascularization is a major cause of blindness. Increased
dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces retinal …
dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces retinal …
Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization
R Yanai, L Mulki, E Hasegawa… - Proceedings of the …, 2014 - National Acad Sciences
Ocular neovascularization, including age-related macular degeneration (AMD), is a primary
cause of blindness in individuals of industrialized countries. With a projected increase in the …
cause of blindness in individuals of industrialized countries. With a projected increase in the …
Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization—brief report
Objective—Regulation of angiogenesis is critical for many diseases. Specifically,
pathological retinal neovascularization, a major cause of blindness, is suppressed with …
pathological retinal neovascularization, a major cause of blindness, is suppressed with …
Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization
E Hasegawa, S Inafuku, L Mulki… - Proceedings of the …, 2017 - National Acad Sciences
Age-related macular degeneration (AMD) is the most common cause of blindness for
individuals age 50 and above in the developed world. Abnormal growth of choroidal blood …
individuals age 50 and above in the developed world. Abnormal growth of choroidal blood …
[HTML][HTML] Fenofibrate inhibits cytochrome P450 epoxygenase 2C activity to suppress pathological ocular angiogenesis
Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-
related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 …
related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 …
[HTML][HTML] ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases
Neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and
age-related macular degeneration, threaten the visual health of children and adults. Current …
age-related macular degeneration, threaten the visual health of children and adults. Current …
[HTML][HTML] Attenuation of choroidal neovascularization by dietary intake of ω-3 long-chain polyunsaturated fatty acids and lutein in mice
Dietary ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and lutein each protect
against age-related macular degeneration (AMD). We here examined the effects of ω-3 …
against age-related macular degeneration (AMD). We here examined the effects of ω-3 …
5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids
Lipid signaling is dysregulated in many diseases with vascular pathology, including cancer,
diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration. We …
diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration. We …
[HTML][HTML] Adiponectin mediates dietary omega-3 long-chain polyunsaturated fatty acid protection against choroidal neovascularization in mice
Purpose: Neovascular age-related macular degeneration (AMD) is a major cause of legal
blindness in the elderly. Diets with omega3-long-chain-polyunsaturated-fatty-acid (ω3 …
blindness in the elderly. Diets with omega3-long-chain-polyunsaturated-fatty-acid (ω3 …