Renal cell carcinoma originates from the lining of the proximal convoluted renal tubule and
represents the most common type of kidney cancer. Risk factors and comorbidities might be …

Background Germline pathogenic variants are estimated to affect 3–5% of patients with
renal cell carcinoma (RCC). The identification of patients with hereditary RCC is important …

Hereditary renal cancer syndromes represent approximately 5% of renal malignancies and
have distinctive clinical, histopathologic, and genetic features. Next-generation sequencing …

Context Hereditary cases account for about 5% of all cases of renal cell carcinoma (RCC).
With advances in next-generation sequencing, several new hereditary syndromes have …

4581 Background: Kidney cancer accounts for 2-3% of all new cancers with clear cell renal
cell carcinoma (ccRCC) the most common subtype. ccRCC is characterized by a high level …

Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although
systematic gene sequencing studies revealed that as many as 5% of renal cell carcinomas …

Background Renal cell carcinoma (RCC) is a disease of genomic alterations, of which the
complete panorama helps in facilitating molecular-guided therapy. Germline mutation …

Importance Identification of patients with hereditary renal cell carcinoma (RCC) is important
for cancer screening and, in patients with advanced disease, for guiding treatment. The …

Background Every year more than 800 patients in Denmark are diagnosed with renal cell
carcinoma (RCC) of which 3–5% are expected to be part of a hereditary renal cancer …

616 Background: We report our experience with next-generation sequencing to characterize
the prevalence and genomic landscape of actionable genomic alterations in renal cell …