The epidermal growth factor receptor (EGFR) family consists of four members that belong to
the ErbB lineage of proteins (ErbB1–4). These receptors consist of an extracellular domain …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

The ErbB/HER protein-tyrosine kinases, which include the epidermal growth factor receptor,
consist of a growth-factor-binding ectodomain, a single transmembrane segment, an …

The EGFR family is among the most investigated receptor protein-tyrosine kinase groups
owing to its general role in signal transduction and in oncogenesis. This family consists of …

We report the use of structure-based drug design to create a selective erbB-1 (aka
epidermal growth factor receptor) and erbB-2 (aka neu/her2 growth factor receptor) tyrosine …

Conventional anticancer therapy using cytotoxic drugs lacks selectivity and is prone to
toxicity and drug resistance. Anticancer therapies targeting aberrant growth factor receptor …

Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, also known
as ErbB or HER, plays crucial roles in the development of multicellular organisms. Mutations …

Recent crystallographic studies have provided significant new insight into how receptor
tyrosine kinases from the EGF receptor or ErbB family are regulated by their growth factor …

Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …