[HTML][HTML] Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: Chemistry, pharmacokinetics, and molecular targets

SF De Silva, J Alcorn - Pharmaceuticals, 2019 - mdpi.com
Cancer causes considerable morbidity and mortality across the world. Socioeconomic,
environmental, and lifestyle factors contribute to the increasing cancer prevalence …

Flaxseed lignans: source, biosynthesis, metabolism, antioxidant activity, bio‐active components, and health benefits

A Touré, X Xueming - … reviews in food science and food safety, 2010 - Wiley Online Library
Lignans are compounds found in a variety of plant materials including flaxseed, pumpkin
seed, sesame seed, soybean, broccoli, and some berries. The major lignan in flaxseed is …

[HTML][HTML] The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells

S Tannous, T Haykal, J Dhaini, MH Hodroj… - Biomedicine & …, 2020 - Elsevier
Flaxseeds have been known for their anti-cancerous effects due to the high abundance of
lignans released upon ingestion. The most abundant lignan, secoisolariciresinol diglucoside …

[HTML][HTML] Naturally lignan-rich foods: A dietary tool for health promotion?

C Rodríguez-García, C Sánchez-Quesada, E Toledo… - Molecules, 2019 - mdpi.com
Dietary guidelines universally advise adherence to plant-based diets. Plant-based foods
confer considerable health benefits, partly attributable to their abundant micronutrient (eg …

9Experimental studies on lignans and cancer

LU Thompson - Bailliere's clinical endocrinology and metabolism, 1998 - Elsevier
Mammalian lignans are produced from plant precursors such as secoisolariciresinol
diglycoside (SDG) and matairesinol via the action of bacteria in the human or animal colon …

[HTML][HTML] Natural polyphenols for prevention and treatment of cancer

Y Zhou, J Zheng, Y Li, DP Xu, S Li, YM Chen, HB Li - Nutrients, 2016 - mdpi.com
There is much epidemiological evidence that a diet rich in fruits and vegetables could lower
the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols …

A comprehensive meta‐analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations

G Grosso, J Godos… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope To summarize available evidence on the association between dietary flavonoid as
well as lignan intake and cancer risk in observational studies. Methods and results A …

[HTML][HTML] Current understanding of flavonoids in cancer therapy and prevention

M Farhan, A Rizvi, M Aatif, A Ahmad - Metabolites, 2023 - mdpi.com
Cancer is a major cause of death worldwide, with multiple pathophysiological
manifestations. In particular, genetic abnormalities, inflammation, bad eating habits …

Flax lignansanalytical methods and how they influence our understanding of biological activity

AD Muir - Journal of AOAC International, 2006 - academic.oup.com
Flaxseed (Linum usitatissimum L.) is a major source of dietary intake of lignans by virtue of
the high concentrations (0.71. 5) that are present in the seed. The principal lignan present in …

Dietary lignans: potential role in cancer prevention

AL Webb, ML McCullough - Nutrition and cancer, 2005 - Taylor & Francis
Recent in vitro, animal, and epidemiological studies suggest that dietary lignans may be
chemopreventive, potentially through anti-estrogenic, anti-angiogenic, pro-apoptotic, and …