Regulation of the opposing kinesin and dynein motors that drive axonal transport is
essential to maintain neuronal homeostasis. Here, we examine coordination of motor activity …

Alzheimer's β-amyloid precursor protein (APP) associates with kinesin-1 via JNK-interacting
protein 1 (JIP1); however, the role of JIP1 in APP transport by kinesin-1 in neurons remains …

Neuronal development, function and repair critically depend on axonal transport of vesicles
and protein complexes, which is mediated in part by the molecular motor kinesin‐1. Adaptor …

Long-distance organelle transport toward axon terminals, critical for neuron development
and function, is driven along microtubules by kinesins [1, 2]. The biophysics of force …

Neurons rely on microtubule (MT) motor proteins such as kinesin‐1 and dynein to transport
essential cargos between the cell body and axon terminus. Defective axonal transport …

The transmembrane protein amyloid-β precursor protein (APP) and the vesicle-associated
protein c-Jun NH2-terminal kinase–interacting protein-1 (JIP-1) are transported into axons …

Autophagy is essential for maintaining cellular homeostasis in neurons, where
autophagosomes undergo robust unidirectional retrograde transport along axons. We find …

The MAP kinase and motor scaffold JIP3 prevents excess lysosome accumulation in axons
of vertebrates and invertebrates. How JIP3's interaction with dynein and kinesin-1 …

Amyloid precursor protein (APP) is the precursor molecule of β-amyloid peptides, the major
components of amyloid plaque in patients with Alzheimer's disease. In this study, we …

Bidirectional axonal transport driven by kinesin and dynein along microtubules is critical to
neuronal viability and function. To evaluate axonal transport mechanisms, we developed a …