Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …

After intense scientific exploration and more than a decade of failed trials, Alzheimer's
disease (AD) remains a fatal global epidemic. A traditional research and drug development …

This decade has seen the beginning of ground-breaking conceptual shifts in the research of
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …

Precision medicine (PM) is an evolving scientific renaissance movement implementing key
breakthrough technological and scientific advances to overcome the limitations of traditional …

Massive investment and technological advances in the collection of extensive and
longitudinal information on thousands of Alzheimer patients results in large amounts of data …

The Precision Neurology development process implements systems theory with system
biology and neurophysiology in a parallel, bidirectional research path: a combined …

Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

These results establish the basis for a deliberate integration of computational biology and
neuroscience into clinical approaches for elucidating cellular mechanisms of disease. In the …

One of the main challenges for healthcare systems is the increasing prevalence of
neurodegenerative pathologies together with the rapidly aging populations. The enormous …

Abstract In Western societies, Alzheimer's disease (AD) is the most common form of
dementia and the sixth leading cause of death. In recent years, the concept of precision …