Tumor microenvironment is known to play important roles in tumor progression. Many
therapies, targeting the tumor microenvironment, are designed and applied in the clinic. One …

After 100 years of debate, it is clear that cancer is recognized by the immune system and this
has generated immense interest in cancer immunotherapy. The systemic nature of the …

Vaccination has had a tremendous impact on human health by harnessing the immune
system to prevent and eradicate infectious diseases and this same approach might be used …

In situ vaccination is an emerging cancer treatment strategy that uses local therapies to
stimulate a systemic antitumor immune response. We previously reported an in situ …

Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV)
to exert systemic immunologic effects on metastases and improve survival. We have utilized …

Targeting drugs to the tumor microenvironment has long been appreciated as a means of
increasing local concentrations and decreasing systemic toxicities. How drug targeting might …

After a long period of endeavor, immunotherapy has become the mainstream of cancer
therapies. This success is mostly ascribed to immune checkpoint blockade, chimeric antigen …

Simple Summary In situ vaccination (ISV) envisages the intratumoral injection of
immunostimulatory molecules, which inflame the tumor and induce anti-tumor immune …

Immunotherapy, where the patient's own immune system is exploited to eliminate tumor
cells, has become one of the most prominent new cancer treatment options in the last …

The identification of tumor-specific antigens and the immune responses directed against
them has instigated the development of therapies to enhance antitumor immune responses …