Abstract Background and Objective Most women with early stage breast cancer have the
option of breast conserving therapy, which involves a partial mastectomy for removal of the …

This study investigates the use of two spectroscopic techniques, auto-fluorescence lifetime
measurement (AFLM) and light reflectance spectroscopy (LRS), for detecting invasive ductal …

Background In over 20% of breast conserving operations, postoperative pathological
assessment of the excised tissue reveals positive margins, requiring additional surgery …

Introduction Residual cancer following breast conserving surgery increases the risk of local
recurrence and mortality. Margin assessment presents an unmet clinical need. Breast tissue …

Recognition of the tumor during breast-conserving surgery (BCS) can be very difficult and
currently a robust method of margin assessment for the surgical setting is not available. As a …

As many as 20-70% of patients undergoing breast conserving surgery require repeat
surgeries due to a close or positive surgical margin diagnosed post-operatively [1]. Currently …

BACKGROUND: In women undergoing breast conserving surgery (BCS), up to 60% can
require re-excision. Our objective is to develop an optically based technology which can …

Purpose: A new approach to spectroscopic imaging was developed to detect and
discriminate microscopic pathologies in resected breast tissues; diagnostic performance of …

Background Breast cancer surgeons struggle with differentiating healthy tissue from cancer
at the resection margin during surgery. We report on the feasibility of using diffuse …

In an ongoing effort to address the clear clinical unmet needs surrounding breast conserving
surgery (BCS), our group has developed a next-generation multiplexed optical-fiber-based …