A role for tetraspanin proteins in regulating fusion induced by Burkholderia thailandensis

A Elgawidi, MI Mohsin, F Ali, A Watts, PN Monk… - Medical Microbiology …, 2020 - Springer
Burkholderia pseudomallei is the causative agent of melioidosis, a disease with high
morbidity that is endemic in South East Asia and northern Australia. An unusual feature of …

Multinucleated Giant Cell Formation and Apoptosis in Infected Host Cells Is Mediated by Burkholderia pseudomallei Type III Secretion Protein BipB

S Suparak, W Kespichayawattana, A Haque… - Journal of …, 2005 - Am Soc Microbiol
Here we have assessed the role of a type III translocator protein, BipB, in the cell biology
and virulence of Burkholderia pseudomallei. Genetic inactivation of bipB reduced …

Tetraspanins are involved in Burkholderia pseudomallei-induced cell-to-cell fusion of phagocytic and non-phagocytic cells

T Sangsri, N Saiprom, A Tubsuwan, P Monk… - Scientific Reports, 2020 - nature.com
Tetraspanins are four-span transmembrane proteins of host cells that facilitate infections by
many pathogens. Burkholderia pseudomallei is an intracellular bacterium and the causative …

Burkholderia pseudomallei Induces Cell Fusion and Actin-Associated Membrane Protrusion: a Possible Mechanism for Cell-to-Cell Spreading

W Kespichayawattana, S Rattanachetkul… - Infection and …, 2000 - Am Soc Microbiol
Burkholderia pseudomallei, a facultative intracellular bacterium, is the causative agent of a
broad spectrum of diseases collectively known as melioidosis. Its ability to survive inside …

Exploitation of host cells by Burkholderia pseudomallei

MP Stevens, EE Galyov - International Journal of Medical Microbiology, 2004 - Elsevier
Intracellular bacterial pathogens have evolved mechanisms to enter and exit eukaryotic cells
using the power of actin polymerisation and to subvert the activity of cellular enzymes and …

[HTML][HTML] Burkholderia pseudomallei-induced cell fusion in U937 macrophages can be inhibited by monoclonal antibodies against host cell surface molecules

S Suparak, V Muangsombut, D Riyapa, JM Stevens… - Microbes and …, 2011 - Elsevier
Burkholderia pseudomallei induces the formation of multinucleated giant cells in cell
monolayers. After infection of human macrophage-like U937 cells with B. pseudomallei …

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages

G Pegoraro, BP Eaton, RL Ulrich, DJ Lane, JF Ojeda… - BMC microbiology, 2014 - Springer
Abstract Background Burkholderia pseudomallei (Bp), a Gram-negative, motile, facultative
intracellular bacterium is the causative agent of melioidosis in humans and animals. The Bp …

Burkholderia pseudomallei RpoS regulates multinucleated giant cell formation and inducible nitric oxide synthase expression in mouse macrophage cell line (RAW …

P Utaisincharoen, S Arjcharoen, K Limposuwan… - Microbial …, 2006 - Elsevier
Burkholderia pseudomallei is the causative agent of melioidosis. This bacterium can invade
and survive inside the phagocytic and nonphagocytic cells. After internalization, the bacteria …

Entry, intracellular survival, and multinucleated-giant-cell-forming activity of Burkholderia pseudomallei in human primary phagocytic and nonphagocytic cells

L Whiteley, T Meffert, M Haug… - Infection and …, 2017 - Am Soc Microbiol
The human pathogen Burkholderia pseudomallei and the related species Burkholderia
thailandensis are facultative intracellular bacteria characterized by the ability to escape into …

Role for the Burkholderia pseudomallei Type Three Secretion System Cluster 1 bpscN Gene in Virulence

T D'Cruze, L Gong, P Treerat, G Ramm… - Infection and …, 2011 - Am Soc Microbiol
Burkholderia pseudomallei, the causal agent of melioidosis, employs a number of virulence
factors during its infection of mammalian cells. One such factor is the type three secretion …