Mitochondria are functionally versatile organelles. In addition to their conventional role of
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …

Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles.
In the past two decades, mitochondria have emerged as signaling organelles that contribute …

The innate immune system has a key role in the mammalian immune response. Recent
research has demonstrated that mitochondria participate in a broad range of innate immune …

Lack of immune system cells or impairment in differentiation of immune cells is the basis for
many chronic diseases. Metabolic changes could be the root cause for this immune cell …

Mitochondria are versatile organelles and essential components of numerous biological
processes such as energy metabolism, signal transduction, and cell fate determination. In …

Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …

Mitochondria are intracellular organelles that originate from a bacterial symbiont, and they
retain multiple features of this bacterial ancestry. The immune system evolved to detect the …

A growing literature indicates that mitochondria are key participants in innate immune
pathways, functioning as both signaling platforms and contributing to effector responses. In …

The immune system of vertebrates confers protective mechanisms to the host through the
sensing of stress-induced agents expressed during infection or cell stress. Among them, the …

Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of
diseases and disorders. Whilst classically the role of these archetypical 'powerhouses' in …