Measurement of antigen-specific T cell responses is an adjunctive parameter to evaluate
protection induced by a previous Bordetella pertussis infection or vaccination. The …

To advance research and development of improved pertussis vaccines, new immunoassays
are needed to qualify the outcome of Bordetella pertussis (Bp) specific CD4+ T-cell …

Introduction The characterization of B. pertussis (Bp) antigen-specific CD4+ T cell cytokine
responses should be included in the evaluation of immunogenicity of pertussis vaccines but …

The recent increase in whooping cough in vaccinated populations has been attributed to
waning immunity associated with the acellular vaccine. The Immune Epitope Database …

We studied the time course of serum IgG antibodies against 3 different pertussis vaccine
antigens: PT (pertussis toxin), FHA (filamentous hemagglutinin), Prn (pertactin) in sera from …

Acellular pertussis vaccines are being evaluated in multiple clinical studies, and human
immunogenicity data will likely be pivotal in the appraisal of vaccine responses between …

Introduction Despite extensive vaccinations, there have been pertussis epidemics in many
countries including the Netherlands, the UK, Australia and the USA. During these epidemics …

Bordetella pertussis is the causative agent of whooping cough, commonly referred to as
pertussis. Although the incidence of pertussis was reduced through vaccination, during the …

The recent immunological investigations, stemming from the studies performed in the
nineties within the clinical trials of the acellular pertussis vaccines, have highlighted the …

BACKGROUND: Pertussis toxin (PT) is a specific virulence factor of Bordetella pertussis and
it is included in all acellular pertussis vaccines (aP). Although immunity after infection seems …