Luteolin inhibits Cr (VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways

P Pratheeshkumar, YO Son, SP Divya, RV Roy… - Toxicology and applied …, 2014 - Elsevier
Abstract Hexavalent chromium [Cr (VI)] is a well-known human carcinogen associated with
the incidence of lung cancer. Inhibition of metal induced carcinogenesis by a dietary …

Protective effect of luteolin on cigarette smoke extract‑induced cellular toxicity and apoptosis in normal human bronchial epithelial cells via the Nrf2 pathway

X Tan, P Jin, L Feng, J Song, E Sun… - Oncology …, 2014 - spandidos-publications.com
Luteolin, one of the most common abundant flavonoids in vegetables and herbs, has
antitumor effects on various tumors by inducing apoptosis, antioxidant effects and inhibition …

Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro

F Wu, H Sun, T Kluz, HA Clancy, K Kiok… - Toxicology and applied …, 2012 - Elsevier
Hexavalent chromium [Cr (VI)] is a human carcinogen that results in the generation of
reactive oxygen species (ROS) and a variety of DNA lesions leading to cell death …

Different roles of ROS and Nrf2 in Cr (VI)-induced inflammatory responses in normal and Cr (VI)-transformed cells

RV Roy, P Pratheeshkumar, YO Son, L Wang… - Toxicology and applied …, 2016 - Elsevier
Abstract Hexavalent chromium (Cr (VI)) is classified as a human carcinogen. Cr (VI) has
been associated with adenocarcinomas and squamous cell carcinoma of the lung. The …

[HTML][HTML] Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr (VI)-transformed cells through decreased reactive oxygen species …

D Kim, J Dai, LY Fai, H Yao, YO Son, L Wang… - Journal of Biological …, 2015 - ASBMB
Hexavalent chromium (Cr (VI)) compounds are well-established lung carcinogens.
Epidermal growth factor receptor (EGFR) is a tyrosine kinase transmembrane receptor that …

Proteomic analysis of chromium cytotoxicity in cultured rat lung epithelial cells

T Lei, QY He, Z Cai, Y Zhou, YL Wang, LS Si, Z Cai… - …, 2008 - Wiley Online Library
Chromium (Cr) has been widely used in industry for more than one century. Exposure to
hexavalent Cr compounds is strongly associated with increasing risk of lung cancer …

[HTML][HTML] Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway

W Masraksa, S Tanasawet, P Hutamekalin… - Nutrition Research …, 2020 - ncbi.nlm.nih.gov
RESULTS Administration with up to 40 µM luteolin showed no cytotoxic activity on lung
cancer A549 cells or non-cancer MRC-5 cells. Additionally, luteolin at 20–40 µM significantly …

Inflammatory effects of hexavalent chromium in the lung: A comprehensive review

JC Kouokam, I Meaza, JP Wise Sr - Toxicology and applied pharmacology, 2022 - Elsevier
Besides smoking, lung cancer can be caused by other factors, including heavy metals such
as cadmium, nickel, arsenic, beryllium and hexavalent chromium [Cr (VI)], which is used in …

NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium

X Wang, YO Son, Q Chang, L Sun… - Toxicological …, 2011 - academic.oup.com
Abstract Hexavalent chromium [Cr (VI)] is a well-known human carcinogen associated with
the incidence of lung cancer. Although overproduction of reactive oxygen species (ROS) has …

Oxidative stress-related lung dysfunction by chromium(VI): alleviation by Citrus aurantium L.

N Soudani, M Rafrafi, I Ben Amara, A Hakim… - Journal of physiology …, 2013 - Springer
Chromium (VI), a very strong oxidant, causes high cytotoxicity through oxidative stress in
tissue systems. Our study investigated the potential ability of ethanolic Citrus aurantium L …