The protein C anticoagulant pathway converts the coagulation signal generated by thrombin
into an anticoagulant response through the activation of protein C by the thrombin …

The blood coagulation system is activated in response to vascular injury (1, 7, 11, 12).
Binding of factor VII to tissue factor initiates a cascade of reactions that leads to the formation …

The coagulation process presents unusual problems with respect to control mechanisms. To
limit the scope of the review, the protein C anticoagulant pathway will serve as a model to …

The endothelial cell protein C receptor@ PCR) is the most recently identified member O {,
the protein C anticoagulant pathway. Protein C and activaibd protein C (APC) bind to EPCR …

Regulation of the protease thrombin, which can occur by altering the rate of its formation or
inactivation, is thought to be central in controlling the extent to which blood coagulation …

The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va,
cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on …

The protein C anticoagulant pathway regulates thrombin formation. The pathway is triggered
when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. Unlike thrombin …

One of the central features of the coagulation cascade is that each successive step in the
process involves assembly of proteases with regulatory proteins (cofactors) and their …

A natural anticoagulant pathway denoted the protein C system provides specific and efficient
control of blood coagulation. Protein C is the key component of the system and circulates in …

Protein C inhibitor (PCI), a plasma serine protease inhibitor, inhibits several proteases
including the anticoagulant enzyme, activated protein C (APC), and the coagulation …