Major depressive disorder (MDD) is a chronic and recurrent psychiatric condition
characterized by depressed mood, social isolation and anhedonia. It will affect 20% of …

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …

A large body of evidence has emerged linking stressful experiences, particularly from one's
social environment, with psychiatric disorders. However, vast individual differences emerge …

Prevalence, symptoms, and treatment of depression suggest that major depressive
disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is …

Depression is highly prevalent worldwide and associated with significant morbidity and
mortality. Approximately 340 million people worldwide suffer from depression at any given …

Although depression has generally been explained with monoamine theory, it is far more
multifactorial, and therapies that address the disease's pathway have not been developed …

Inflammation is a risk factor for both depression and cardiovascular disease. Depressed
mood is also a cardiovascular risk factor. To date, research into mechanisms through which …

Viable new treatments for depression and anxiety have been slow to emerge, likely owing to
the complex and incompletely understood etiology of these disorders. A budding area of …

Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …