Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …

In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …

The aim of the present study was to provide a comprehensive characterization of whole
genome DNA methylation patterns in replicative and ionizing irradiation-or doxorubicin …

Cellular stress responses influence cell fate decisions. Apoptosis and proliferation represent
opposing reactions to cellular stress or damage and may influence distinct health outcomes …

The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …

Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …

Cellular senescence has emerged as a fundamental biological mechanism underpinning
the ageing process and has been implicated in the pathogenesis of an increasing number of …

Aging is characterized by decreasing physiological integration, reduced function, loss of
resilience, and increased risk of death. Paradoxically, although women live longer, they …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …