We describe a paradigm for nociception in Drosophila. In response to the touch of a probe
heated above 38° C, Drosophila larvae produce a stereotypical rolling behavior, unlike the …

Nociception, warning of injury that should be avoided, serves an important protective
function in animals. In this study, we show that adult Drosophila avoids noxious heat by a …

The word “nociception” is derived from the Latin “nocere,” which means “to harm.”
Nociception refers to the sensory perception of noxious stimuli that have the potential to …

Genetic analysis of nociceptive behaviors in the nematode Caenorhabditis elegans and the
fruit fly Drosophila melanogaster has led to the discovery of conserved sensory transduction …

Here, we describe a targeted reverse genetic screen for thermal nociception genes in
Drosophila larvae. Using laser capture microdissection and microarray analyses of …

Nociception refers to the process of encoding and processing noxious stimuli, which allow
animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger …

Highly branched class IV multidendritic sensory neurons of the Drosophila larva function as
polymodal nociceptors that are necessary for behavioral responses to noxious heat (> 39° …

Pain is a significant medical concern and represents a major unmet clinical need. The ability
to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily …

The basic mechanisms underlying noxious cold perception are not well understood. We
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …

Upon perception of a noxious stimulus, an organism executes defense mechanisms, such
as escape responses. The molecular basis of these mechanisms is poorly understood. In …