Background: Osteoporosis is an important medical and social public health problem in an
aging or elderly society. Osteoporosis is caused by an imbalance in bone remodeling, which …

The fact is disturbance of the processes of bone tissue remodeling leads to a change in the
balance between synthesis and resorption of bone and the development of osteoporosis …

Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management
of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions …

Glucocorticoids (GCs) exert potent, but poorly characterized, effects on the skeleton. The
cellular activity of GCs is regulated at a prereceptor level by 11β-hydroxysteroid …

Bone remodeling is essential for skeletal and the whole body health. Imbalance in skeletal
turnover, so that bone resorption exceeds bone formation, may lead to reduction in bone …

Until recently it was assumed that there was a direct relationship between the level of
glucocorticoids in the circulation and the levels within tissue. The identification and …

Abstract 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) plays an important role in pre-
receptor glucocorticoid metabolism. This enzyme is expressed in bone, increases with age …

Both central obesity and osteoporosis are common findings in states of glucocorticoid
excess. In many tissues, including adipose tissue, 11β-hydroxysteroid dehydrogenase type …

The risk of glucocorticoid‐induced osteoporosis increases substantially with age but there is
considerable individual variation. In recent studies we have shown that the effects of …

In the past decades, concern on glucocorticoid-induced osteoporosis has increased with the
widespread use of exogenous glucocorticoids (GC). Mature bone-forming cells (osteoblasts) …