Alcohol use disorder (AUD) is frequently comorbid with mood disorders, and these co-
occurring neuropsychiatric disorders contribute to the development and maintenance of …

Alcohol use disorder is highly comorbid with other neuropsychiatric disorders such as
depression and anxiety. Importantly, women and men are affected differentially by heavy …

Background Alcohol withdrawal is a key component of severe alcohol use disorder. Animal
models of alcohol withdrawal tend to focus on traditional anxiety/stress tests. While these …

Negative reinforcement is widely thought to play an important role in chronic alcohol‐use
disorders (AUDs), and high comorbidity between AUDs and affective disorders highlights …

Background Alcohol use disorders are characterized by a complex behavioral
symptomatology, which includes the loss of control over alcohol consumption and the …

Comorbidity between alcohol use and anxiety disorders is associated with more severe
symptoms and poorer treatment outcomes than either of the conditions alone. There is a well …

Alcohol use is one of the world's leading causes of death and disease, although only a small
proportion of individuals develop persistent alcohol use disorder (AUD). The identification of …

Cessation from chronic alcohol abuse often produces a dysphoric state that can persist into
protracted withdrawal. This dysphoric state is theorized to function as a negative reinforcer …

A prior history of excessive drinking induces a negative affective state in both humans and
laboratory rodents, the manifestation of which varies with the age of drinking-onset. In …

Introduction Alcohol abuse is a risk factor for affective and cognitive disorders, with evidence
indicating that adolescent-onset excessive drinking can result in long-term deficiencies in …