Contribution of phosphate and FGF23 to CKD progression

KP Jansson, SL Alan, JR Stubbs - Current opinion in nephrology …, 2022 - journals.lww.com
Studies presented in this review highlight important scientific discoveries that have molded
our current understanding of the contribution of altered phosphate homeostasis to CKD …

Rationale and approaches to phosphate and fibroblast growth factor 23 reduction in CKD

T Isakova, JH Ix, SM Sprague, KL Raphael… - Journal of the …, 2015 - journals.lww.com
Patients with CKD often progress to ESRD and develop cardiovascular disease (CVD), yet
available therapies only modestly improve clinical outcomes. Observational studies report …

Continued search for therapies to favorably modify phosphate and FGF23 levels in CKD

R Mehta, T Isakova - Clinical Journal of the American Society of …, 2017 - journals.lww.com
Over the last two decades, scientific developments have enhanced our understanding of the
pathogenesis of cardiovascular disease in patients with CKD, and specific nontraditional risk …

[HTML][HTML] The importance of phosphate control in chronic kidney disease

K Tsuchiya, T Akihisa - Nutrients, 2021 - mdpi.com
A series of problems including osteopathy, abnormal serum data, and vascular calcification
associated with chronic kidney disease (CKD) are now collectively called CKD-mineral bone …

[HTML][HTML] Hyperphosphatemia with elevated serum PTH and FGF23, reduced 1,25(OH)2D and normal FGF7 concentrations characterize patients with CKD

K Kritmetapak, L Losbanos, TE Berent… - BMC nephrology, 2021 - Springer
Background Hyperphosphatemia confers adverse cardiovascular outcomes, and commonly
occurs in late-stage CKD. Fibroblast growth factor 7 (FGF7) is a phosphaturic peptide which …

Management of hyperphosphataemia in chronic kidney disease—challenges and solutions

M Ketteler, RP Wüthrich, J Floege - Clinical kidney journal, 2013 - academic.oup.com
Hyperphosphataemia is a clinical consequence of the advanced stages of chronic kidney
disease (CKD). Considerable evidence points to a role of hyperphosphataemia in the …

Phosphate metabolism in CKD stages 3–5: dietary and pharmacological control

M Ketteler - International Journal of Nephrology, 2011 - Wiley Online Library
When compared to the available information for patients on dialysis (CKD stage 5D), data on
the epidemiology and appropriate treatment of calcium and phosphate metabolism in the …

Contemporary management of phosphorus retention in chronic kidney disease: a review

FS Amiri - Clinical and experimental nephrology, 2015 - Springer
Hyperphosphatemia is the most common metabolic complications of end-stage kidney
disease (ESKD). Large observational studies have identified hyperphosphatemia as an …

Disturbance of phosphorus metabolism in chronic kidney disease

H Komaba, M Fukagawa - Clinical Calcium, 2009 - europepmc.org
The kidney plays a central role in the maintenance of phosphorus homeostasis. Thus
disturbance of phosphorus metabolism develops in most patients with chronic kidney …

Kidney toxicity of phosphate: is that crystal clear yet?

E Letavernier, TB Drüeke - Kidney International, 2021 - kidney-international.org
Hyperphosphatemia is a well-known feature of advanced chronic kidney disease (CKD) and
a major risk factor for cardiovascular events in patients with CKD, inducing calcium …