[HTML][HTML] Effect of spermidine on ameliorating spermatogenic disorders in diabetic mice via regulating glycolysis pathway

JY Wang, D Ma, M Luo, YP Tan, O Zhong… - Reproductive Biology …, 2022 - Springer
Diabetes mellitus (DM), a high incidence metabolic disease, is related to the impairment of
male spermatogenic function. Spermidine (SPM), one of the biogenic amines, was identified …

Metformin ameliorates testicular damage in male mice with streptozotocin‐induced type 1 diabetes through the PK2/PKR pathway

Y Liu, Z Yang, D Kong, Y Zhang… - Oxidative medicine and …, 2019 - Wiley Online Library
Approximately 90% of male diabetes mellitus patients have varying degrees of testicular
dysfunction. The molecular mechanism underlying diabetes‐induced testicular damage has …

Effects of experimental diabetes on testis proliferations and apoptosis in rats

C Aktas, M Kanter, M Erboğa… - Journal of experimental …, 2011 - dergipark.org.tr
This work aimed to investigate the role of diabetes on cell proliferation, and apoptosis in
testis. The rats were randomly allotted into one of two experimental groups: control and …

[HTML][HTML] Testicular histopathology and phosphorylated protein changes in mice with diabetes induced by multiple-low doses of streptozotocin: An experimental study

A Sampannang, S Arun, J Burawat… - International Journal …, 2018 - ncbi.nlm.nih.gov
Background: The streptozotocin (STZ)-induced diabetic model is widely used to evaluate the
adverse effects of diabetes mellitus (DM) on spermatogenesis and testicular …

[HTML][HTML] Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway: Nicotinamide …

D Ma, L Hu, J Wang, M Luo, A Liang, X Lei… - Acta Biochimica et …, 2022 - ncbi.nlm.nih.gov
Spermatogenic dysfunction is one of the major secondary complications of diabetes;
however, the underlying mechanisms remain ill-defined, and there is no available drug or …

Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model

Y Xu, H Lei, R Guan, Z Gao, H Li, L Wang… - Biochemical and …, 2014 - Elsevier
Streptozotocin (STZ) induced diabetic model has been widely used to study the effects of
diabetes mellitus (DM) on male infertility, but it remains unclear whether the responses in …

[HTML][HTML] Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis

CC Maresch, DC Stute, T Fleming, J Lin… - Scientific Reports, 2019 - nature.com
Diabetes-induced hyperglycemia has previously been shown to impact on male sub-
/infertility, however, still little is known about the underlying mechanisms. In the present study …

The effect of streptozotocin induced diabetes on sperm function: a closer look at AGEs, RAGEs, MAPKs and activation of the apoptotic pathway

TS Omolaoye, SS Du Plessis - Toxicological Research, 2021 - Springer
This study was designed to (1) investigate the possible mechanisms through which diabetes-
induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) activation …

Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats

ASM Khalil, N Giribabu, S Yelumalai, H Shahzad… - Life sciences, 2021 - Elsevier
Diabetes mellitus (DM) may lead to testicular-related infertility while Myristic acid (MA) is
beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes …

Gynura procumbens Improved Fertility of Diabetic Rats: Preliminary Study of Sperm Proteomic

KA Kamaruzaman, WM Aizat… - … and Alternative Medicine, 2018 - Wiley Online Library
Gynura procumbens (GP) is a medicinal herb that has long been known as anti‐
inflammatory and antihyperglycaemic. Recently, this herbal extract has been associated with …