Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles

EM Elmowafy, M Tiboni, ME Soliman - Journal of Pharmaceutical …, 2019 - Springer
Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …

PLGA-based nanoparticles: an overview of biomedical applications

F Danhier, E Ansorena, JM Silva, R Coco… - Journal of controlled …, 2012 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …

Poly (lactic-co-glycolic acid) microsphere production based on quality by design: a review

Y Hua, Y Su, H Zhang, N Liu, Z Wang, X Gao, J Gao… - Drug Delivery, 2021 - Taylor & Francis
Poly (lactic-co-glycolic acid)(PLGA) has garnered increasing attention as a candidate drug
delivery polymer owing to its favorable properties, including its excellent biocompatibility …

PLGA: a unique polymer for drug delivery

DN Kapoor, A Bhatia, R Kaur, R Sharma… - Therapeutic …, 2015 - Taylor & Francis
Biodegradable polymers have played an important role in the delivery of drugs in a
controlled and targeted manner. Polylactic-co-glycolic acid (PLGA) is one of the extensively …

Poly (lactic acid)-based microparticles for drug delivery applications: An overview of recent advances

A Vlachopoulos, G Karlioti, E Balla, V Daniilidis… - Pharmaceutics, 2022 - mdpi.com
The sustained release of pharmaceutical substances remains the most convenient way of
drug delivery. Hence, a great variety of reports can be traced in the open literature …

Recent applications of PLGA based nanostructures in drug delivery

M Mir, N Ahmed, A ur Rehman - Colloids and Surfaces B: Biointerfaces, 2017 - Elsevier
Over the years, issues associated with non-biodegradable polymers have paved the way for
biodegradable polymers in the domain of pharmaceutical and biomedical sciences. Poly …

Poly (lactic acid)-based particulate systems are promising tools for immune modulation

C Peres, AI Matos, J Conniot, V Sainz, E Zupančič… - Acta biomaterialia, 2017 - Elsevier
Abstract Poly (lactic acid)(PLA) is one of the most successful and versatile polymers
explored for controlled delivery of bioactive molecules. Its attractive properties of …

Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics

D Ding, Q Zhu - Materials Science and Engineering: C, 2018 - Elsevier
Recent advancements in biopharmaceutical industry have facilitated the development of
novel bioactive macromolecular therapeutics. One of the challenges towards the clinical use …

PLGA-based nanoparticles: A new paradigm in biomedical applications

S Sharma, A Parmar, S Kori, R Sandhir - TrAC trends in analytical chemistry, 2016 - Elsevier
Polymers were first introduced three decades ago as bioresorbable surgical devices. Since
then, polymer-based nanoparticles have been extensively studied in a variety of fields …

PLGA-based nanomedicine: history of advancement and development in clinical applications of multiple diseases

HO Alsaab, FD Alharbi, AS Alhibs, NB Alanazi… - Pharmaceutics, 2022 - mdpi.com
Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …