A well plate-based GelMA photo-crosslinking system with tunable hydrogel mechanical properties to regulate the PTH-mediated osteogenic fate

K Paek, S Woo, SJ Song, MK Kim, K Yi, S Chung… - …, 2024 - iopscience.iop.org
Versatile and efficient regulation of the mechanical properties of the extracellular matrix is
crucial not only for understanding the dynamic changes in biological systems, but also for …

Tuning Physical Properties of GelMA Hydrogels through Microarchitecture for Engineering Osteoid Tissue

E Walejewska, FPW Melchels, A Paradiso… - …, 2023 - ACS Publications
Gelatin methacryloyl (GelMA) hydrogels have gained significant attention due to their
biocompatibility and tunable properties. Here, a new approach to engineer GelMA-based …

Integrating Mechanics and Bioactivity: A Detailed Assessment of Elasticity and Viscoelasticity at Different Scales in 2D Biofunctionalized PEGDA Hydrogels for …

C López-Serrano, Y Côté-Paradis… - … Applied Materials & …, 2024 - ACS Publications
Methods for promoting and controlling the differentiation of human mesenchymal stem cells
(hMSCs) in vitro before in vivo transplantation are crucial for the advancement of tissue …

Photoresponsive hydrogels with photoswitchable mechanical properties allow time-resolved analysis of cellular responses to matrix stiffening

IN Lee, O Dobre, D Richards, C Ballestrem… - … applied materials & …, 2018 - ACS Publications
As cell function and phenotype can be directed by the mechanical characteristics of the
surrounding matrix, hydrogels have become important platforms for cell culture systems, with …

Regulation of stem cell fate in a three‐dimensional micropatterned dual‐crosslinked hydrogel system

O Jeon, E Alsberg - Advanced functional materials, 2013 - Wiley Online Library
Micropatterning technology is a powerful tool for controlling the cellular microenvironment
and investigating the effects of physical parameters on cell behaviors, such as migration …

Dynamic stiffening hydrogel with instructive stiffening timing modulates stem cell fate in vitro and enhances bone remodeling in vivo

X Li, S Liu, S Han, Q Sun, J Yang… - Advanced …, 2023 - Wiley Online Library
Biomechanical stimuli derived from the extracellular matrix (ECM) extremely tune stem cell
fate through 3D and spatiotemporal changes in vivo. The matrix stiffness is a crucial factor …

Biofabrication of cell-laden gelatin methacryloyl hydrogels with incorporation of silanized hydroxyapatite by visible light projection

JJM Su, CH Lin, H Chen, SY Lee, YM Lin - Polymers, 2021 - mdpi.com
Gelatin methacryloyl (GelMA) hydrogel is a photopolymerizable biomaterial widely used for
three-dimensional (3D) cell culture due to its high biocompatibility. However, the drawback …

Photo-driven dynamic hydrogel modulates bone marrow mesenchymal stem cells behavior for enhanced cartilage regeneration

W Zhang, W Xue, Z Jia, R Yang, P Wang, Y Hu… - Chemical Engineering …, 2024 - Elsevier
Regenerating damaged cartilage remains a challenge due to limited cell availability and
inefficient chondrogenic differentiation. Here, we present a photo-driven dynamic hydrogel …

Soft hydrogels for balancing cell proliferation and differentiation

Q Wei, J Young, A Holle, J Li, K Bieback… - ACS biomaterials …, 2020 - ACS Publications
Hydrogels have been widely explored for the delivery of cells in a variety of regenerative
medicine applications due to their ability to mimic both the biochemical and physical cues of …

Photo-crosslinkable, bone marrow-derived mesenchymal stem cells-encapsulating hydrogel based on collagen for osteogenic differentiation

T Zhang, H Chen, Y Zhang, Y Zan, T Ni, M Liu… - Colloids and Surfaces B …, 2019 - Elsevier
Many patients suffer from bone injury and self-regeneration is not effective. Developing new
strategies for effective bone injury repair is highly desired. Herein, collagen, an important …