Cognitive impairment is a common aspect of multiple sclerosis (MS) for which there are no
treatments. Reduced brain N-acetylaspartylglutamate (NAAG) levels are linked to impaired …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease where
muscle weakness and neuromuscular junction (NMJ) denervation precede motor neuron …

Background Neuroinflammation mediated by microglia plays a central role in the
pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics …

Polyamidoamine (PAMAM) dendrimers are multifunctional nanoparticles with tunable
physicochemical features, making them promising candidates for targeted drug delivery in …

Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits
the development of effective treatments for CNS disorders. We present the facile synthesis of …

Aim: Understanding the interactions between nanomaterials and disease processes is
crucial for designing effective therapeutic approaches. This article explores the unusual …

Switching microglia from a disease exacerbating,'pro-inflammatory'state into a
neuroprotective,'anti-inflammatory'phenotype is a promising strategy for addressing multiple …

Dendrimers are polyfunctional nano-objects of perfectly defined structure that can provide
innovative alternatives for the treatment of chronic inflammatory diseases, including multiple …

Neurotherapeutics for the treatment of central nervous system (CNS) disorders must
overcome challenges relating to the blood-brain barrier (BBB), brain tissue penetration, and …

Hyperactivity of microglia and loss of functional circuitry is a common feature of many
neurological disorders including those induced or exacerbated by inflammation. Herein, we …