[HTML][HTML] Revisiting resveratrol as an osteoprotective agent: molecular evidence from in vivo and in vitro studies

H Ahmad Hairi, PA Jayusman, AN Shuid - Biomedicines, 2023 - mdpi.com
Resveratrol (RSV)(3, 5, 4′-trihydroxystilbene) is a stilbene found in abundance in berry
fruits, peanuts, and some medicinal plants. It has a diverse range of pharmacological …

The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1‐bone morphogenic protein 2 longevity axis

M Zhao, SY Ko, IR Garrett, GR Mundy… - British journal of …, 2018 - Wiley Online Library
Background and Purpose The polyphenol resveratrol (RSV) exists in high quantities in
certain foods (eg grapes and nuts). However, the capacity of RSV to confer physiological …

[HTML][HTML] Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy

JC Tou - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Osteoporosis is a major public health issue that is expected to rise as the global population
ages. Resveratrol (RES) is a plant polyphenol with various anti-aging properties. RES …

Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis

A Mobasheri, M Shakibaei - Annals of the New York Academy …, 2013 - Wiley Online Library
There are a number of pharmacological agents for the treatment of bone mineral loss and
osteoporosis. Hormone replacement therapy (HRT) with estrogen is an established …

Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway

J Zhang, R Li, K Man, XB Yang - Pharmaceutical biology, 2022 - Taylor & Francis
Context The osteogenic potential of the human dental pulp stromal cells (hDPSCs) was
reduced in the state of oxidative stress. Resveratrol (RSV) possesses numerous biological …

Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway

J Feng, S Liu, S Ma, J Zhao, W Zhang… - Acta Biochim …, 2014 - academic.oup.com
Postmenopausal osteoporosis severely jeopardizes human health. Seeking for therapeutic
drugs without side effects is of great necessity. Our study was designed to investigate …

Evaluating resveratrol as a therapeutic bone agent: preclinical evidence from rat models of osteoporosis

JC Tou - Annals of the New York Academy of Sciences, 2015 - Wiley Online Library
Resveratrol (RSV) is a naturally occurring plant polyphenol that has potential to attenuate
osteoporosis with distinct pathologies. This review evaluates preclinical evidence regarding …

[HTML][HTML] Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53

T Yu, Z Wang, X You, H Zhou, W He, B Li, J Xia… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Although osteoporosis is one of the most common chronic age-related diseases, there is
currently no gold standard for treatment. Evidence suggests resveratrol, a natural …

Protective effect and possible mechanisms of resveratrol in animal models of osteoporosis: A preclinical systematic review and meta‐analysis

F Lin, J Chen, M Chen, S Lin, S Dong - Phytotherapy Research, 2023 - Wiley Online Library
Resveratrol (RES) has extensively been utilized to treat osteoporosis (OP) in animal models.
However, the anti‐OP effects of RES have not been tested during clinical application due to …

[HTML][HTML] Anti-osteoporotic mechanisms of polyphenols elucidated based on in vivo studies using ovariectomized animals

Y Niwano, H Kohzaki, M Shirato, S Shishido… - Antioxidants, 2022 - mdpi.com
Polyphenols are widely known for their antioxidant activity, ie, they have the ability to
suppress oxidative stress, and this behavior is mediated by the autoxidation of their phenolic …