Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Tumor progression
depends on interactions of cancer cells with the tumor microenvironment. Here, we find …

Telomerase is a ribonucleoprotein enzyme that maintains protective structures at the ends of
eukaryotic chromosomes. Earlier studies have reported that the presence of telomerase …

Non‑small cell lung cancer (NSCLC), which accounts for~ 85% of all lung cancer cases, is
commonly diagnosed at an advanced stage and has a high patient mortality rate. Despite …

In the majority of human malignancies, maintenance of telomeres is achieved by reactivation
of telomerase, whereas a smaller fraction uses an alternative telomere lengthening (ALT) …

Current mouse models of lung cancer recapitulate signature genetic lesions and some
phenotypic features of human lung cancer. However, because mice have long telomeres …

Telomeres are specialized genomic structures that protect chromosomal ends to maintain
genomic stability. Telomeric length is primarily regulated by the telomerase complex …

Telomerase activation is a common feature of most advanced human cancers and is
postulated to restore genomic stability to a level permissive for cell viability and tumor …

Aims: h-TERT is the keystone gene in controlling telomerase expression under the
modulation of many associated genes. Our study was designed to observe the concordant …

Telomerase reverse transcriptase (TERT), the catalytic subunit of the enzyme telomerase, is
robustly expressed in cancer cells. TERT enables cells to avoid chromosome shortening …

Many cancer and immortal cells exhibit telomerase activity that stabilizes telomere lengths,
possibly contributing to cell immortality and carcinogenesis. The aim of this study was to …