The application of the CRISPR-Cas system in antibiotic resistance

S Tao, H Chen, N Li, W Liang - Infection and drug resistance, 2022 - Taylor & Francis
The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance

M Abavisani, R Khayami, M Hoseinzadeh… - Drug Resistance …, 2023 - Elsevier
The phenomenon of antibiotic resistance (AR) and its increasing global trends and
destructive waves concerns patients and the healthcare system. In order to combat AR, it is …

[HTML][HTML] Harnessing the CRISPR-Cas systems to combat antimicrobial resistance

C Duan, H Cao, LH Zhang, Z Xu - Frontiers in Microbiology, 2021 - frontiersin.org
The emergence of antimicrobial-resistant (AMR) bacteria has become one of the most
serious threats to global health, necessitating the development of novel antimicrobial …

How CRISPR-Cas system could be used to combat antimicrobial resistance

P Gholizadeh, Ş Köse, S Dao, K Ganbarov… - Infection and drug …, 2020 - Taylor & Francis
Rapid emergence of antibiotic-resistant bacteria has made it harder for us to combat
infectious diseases and to develop new antibiotics. The clustered regularly interspaced short …

[HTML][HTML] Anti-CRISPR proteins as a therapeutic agent against drug-resistant bacteria

P Vyas - Microbiological research, 2022 - Elsevier
The continuous deployment of various antibiotics to treat multiple serious bacterial infections
leads to multidrug resistance among the bacterial population. It has failed the standard …

[HTML][HTML] CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria

D Palacios Araya, KL Palmer, BA Duerkop - PLoS Pathogens, 2021 - journals.plos.org
The rapid emergence of antibiotic-resistant bacteria and the comparatively limited
development of new antibacterial molecules pose a major threat to modern medicine by …

CRISPR-Cas biology and its application to infectious diseases

JR Strich, DS Chertow - Journal of clinical microbiology, 2019 - Am Soc Microbiol
Infectious diseases remain a global threat contributing to excess morbidity and death
annually, with the persistent potential for destabilizing pandemics. Improved understanding …

CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance

A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

[HTML][HTML] CRISPR-cas system: biological function in microbes and its use to treat antimicrobial resistant pathogens

MAB Shabbir, MZ Shabbir, Q Wu, S Mahmood… - Annals of clinical …, 2019 - Springer
The development of antibiotic resistance in bacteria is a major public health threat. Infection
rates of resistant pathogens continue to rise against nearly all antimicrobials, which has led …

[HTML][HTML] CRISPR-Cas antimicrobials: challenges and future prospects

E Pursey, D Sünderhauf, WH Gaze, ER Westra… - PLoS …, 2018 - journals.plos.org
Antimicrobial resistance (AMR) poses a serious threat to modern medicine and may render
common infections untreatable. The discovery of new antibiotics has come to a relative …