The failure to repair critical‐sized bone defects often leads to incomplete regeneration or
fracture non‐union. Tissue‐engineered grafts have been recognized as an alternative …

The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

In clinical terms, bone grafting currently involves the application of autogenous, allogeneic,
or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as …

Bone fractures are common in clinics and the demand for effective repair material is high.
Unfortunately, limited graft availability, donor site morbidities, unpredictable clinical …

Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized
bone defects to address the unmet need for bone augmentation and skeletal repair. Effective …

The successful regeneration of bone tissue to replace areas of bone loss in large defects or
at load‐bearing sites remains a significant clinical challenge. Over the past few decades …

The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate
lost bone, as demonstrated by the large number of bone graft procedures performed …

Bone tissue engineering approaches have evolved towards addressing the challenges of
tissue mimetic requirements over the years. Different strategies have been combining …

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …