Human T2D is characterized by a low-grade systemic inflammation, loss of β-cells, and
diminished insulin production. Local islet immunity is still poorly understood, and hence, we …

There is increasing evidence showing that chronic inflammation is an important pathogenic
mediator of the development of type 2 diabetes (T2D). It is now generally accepted that …

Hyperglycaemia is a key factor in diabetic pathology. Macrophages are essential regulators
of inflammation which can be classified into two major vectors of polarisation: classically …

Activation of the innate immune system in obesity is a risk factor for the development of type
2 diabetes. The aim of the current study was to investigate the notion that increased …

Islet-specific T cells are essential in the development of type I diabetes. The role of non-
lymphoid cells is relatively unclear, although infiltration of dendritic cells and macrophages …

Macrophages are innate immune cells derived from monocytes, which, in turn, arise from
myeloid precursor cells in the bone marrow. Macrophages have many important roles in the …

In recent years much evidence has been accumulating that the seemingly acute onset of
type I (insulin dependent) diabetes mellitus is in fact the consequence of progressive B-islet …

OBJECTIVE—Type 1 diabetes is an autoimmune disease characterized by a local
inflammatory reaction in and around islets followed by selective destruction of insulin …

Aims Monocytes and macrophages express cell-surface markers indicative of their
inflammatory and activation status. In this study, we investigated whether these markers are …

Aims/hypothesis Mild islet inflammation has been suggested as a contributing factor to beta
cell failure in type 2 diabetes. Macrophage levels are elevated in the islets of humans and …