Recent years have seen tremendous progress towards therapy of many previously incurable
neuromuscular diseases. This new context has acted as a driving force for the development …

Objectives Quantitative magnetic resonance imaging (MRI) can potentially meet the
pressing need for objective, sensitive, reproducible outcome measures in neuromuscular …

There is an unmet need to identify biomarkers sensitive to change in rare, slowly
progressive neuromuscular diseases. Quantitative magnetic resonance imaging (MRI) of …

In skeletal muscle that is structurally normal, 1H NMR T2 is heavily dependent on and
reflective of water mobility in the tissue. Water mobility, measured by its inverse, water …

Neuromuscular diseases are characterized by progressive muscle degeneration and
muscle weakness resulting in functional disabilities. While each of these diseases is …

The muscular dystrophies are rare orphan diseases, characterized by progressive muscle
weakness: the most common and well known is Duchenne muscular dystrophy which affects …

Background A substantial impediment to progress in trials of new therapies in
neuromuscular disorders is the absence of responsive outcome measures that correlate with …

The purpose of this study was to evaluate temporal stability, multi‐center reproducibility and
the influence of covariates on a multimodal MR protocol for quantitative muscle imaging and …

Abnormal signal intensity within skeletal muscle is frequently encountered at magnetic
resonance (MR) imaging. Potential causes are diverse, including traumatic, infectious …

Skeletal muscles of children with Duchenne muscular dystrophy (DMD) show enhanced
susceptibility to damage and progressive lipid infiltration, which contribute to an increase in …