Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents
U Acar Çevik, BN Sağlık, CM Ardıç… - Turkish Journal of …, 2018 - degruyter.com
Objectives Cancer is one of the leading causes of death throughout the world. Current
therapy options suffer from the major limitations of side effects and drug resistance. Thus …
therapy options suffer from the major limitations of side effects and drug resistance. Thus …
Antiproliferative, cytotoxic, and apoptotic effects of new benzimidazole derivatives bearing hydrazone moiety
In order to take the advantages of the anticancer properties of benzimidazoles and
hydrazones, we synthesized new 4‐(5‐chloro‐1 H‐benzimidazol‐2‐yl)‐benzoic acid …
hydrazones, we synthesized new 4‐(5‐chloro‐1 H‐benzimidazol‐2‐yl)‐benzoic acid …
Synthesis and evaluation of new thiazolyl hydrazone derivatives as potential anticancer agents
Z Asım Kaplancıklı, B Sever… - Letters in Drug …, 2017 - ingentaconnect.com
Background: In recent years, thiazole derivatives incorporated with hydrazone moiety have
attracted a great deal of interest due to their pivotal role in the field of current cancer …
attracted a great deal of interest due to their pivotal role in the field of current cancer …
Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
Based on the biologically active heterocycle compounds, a series of new benzimidazole-
hydrazone derivatives (3a-3j) were synthesized, starting from 4-(6-chloro-1H-benzimidazol …
hydrazone derivatives (3a-3j) were synthesized, starting from 4-(6-chloro-1H-benzimidazol …
Synthesis and biological profile of substituted benzimidazoles
N Vashist, SS Sambi, B Narasimhan, S Kumar… - Chemistry Central …, 2018 - Springer
Background A series of benzimidazole derivatives was developed and its chemical scaffolds
were authenticated by NMR, IR, elemental analyses and physicochemical properties. The …
were authenticated by NMR, IR, elemental analyses and physicochemical properties. The …
Synthesis and SAR study of the novel thiadiazole–imidazole derivatives as a new anticancer agents
In the present study, a novel series of 2-(2-(3-aryl-5-substituted-1, 3, 4-thiadiazol-2 (3H)-
ylidene) hydrazinyl)-4, 4-diphenyl-1H-imidazol-5 (4H)-one derivatives were designed and …
ylidene) hydrazinyl)-4, 4-diphenyl-1H-imidazol-5 (4H)-one derivatives were designed and …
Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
Based on the biologically active heterocycle compounds, a series of new benzimidazole-
hydrazone derivatives (3a-3j) were synthesized, starting from 4-(6-chloro-1H-benzimidazol …
hydrazone derivatives (3a-3j) were synthesized, starting from 4-(6-chloro-1H-benzimidazol …
[HTML][HTML] Synthesis, characterization and anticancer evaluation of 2-(naphthalen-1-ylmethyl/naphthalen-2-yloxymethyl)-1-[5-(substituted phenyl)-[1, 3, 4] oxadiazol-2 …
M Shaharyar, A Mazumder, MJ Ahsan - Arabian Journal of Chemistry, 2014 - Elsevier
In the present study o-phenylenediamine and naphtene-1-acetic acid/2-naphthoxyacetic
acid were used as a starting material through a series of steps and 2-(naphthalen-1 …
acid were used as a starting material through a series of steps and 2-(naphthalen-1 …
Synthesis and insight into the structure–activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents
TKC Huynh, THA Nguyen, TCT Nguyen, TKD Hoang - Rsc Advances, 2020 - pubs.rsc.org
In order to explore and develop new anticancer agents, three series of 2-
phenylbenzimidazoles, 15–46, were condensed under simple and mild conditions using …
phenylbenzimidazoles, 15–46, were condensed under simple and mild conditions using …
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo [d] imidazol-1-yl) acetohydrazide derivatives as antitumor agents
T Liu, C Sun, X Xing, L Jing, R Tan, Y Luo… - Bioorganic & medicinal …, 2012 - Elsevier
A novel class of acetylhydrazone derivatives (5a–x) containing 2-(phenylthiomethyl)-1H-
benzo-[d]-imidazole moieties are synthesizer, and their antitumor activities against A549 …
benzo-[d]-imidazole moieties are synthesizer, and their antitumor activities against A549 …
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